From: Joichi Ito
Sent: Saturday, June 6, 2015 2:35 PM
To: Jeffrey Epstein
Subject: Re: Direct Germans

Can I call you from the car in 1 hr?

On Jun 6, 2015, at 10:31 AM, jeffrey E. <jeevacation@gmail.com> wrote:
> 212 772 9416

>

On Sat, Jun 6, 2015 at 10:24 AM, Joichi Ito <blackened out> wrote:
> I again feel like maybe I need to study math. I only know enough to =escribe non-messy things. How do I start?
>
>> On Jun 6, 2015, at 10:22 AM, jeffrey E. <jeevacation@gmail.com> =rote:
>>
>> math is a notation that tries to describe messiness. the more =olistic. shape. mouthiness. is a more elegant way of descrining =ertain concepts and mouthiness for a characteristic of food ( temp =hewiness. tastes )

>>

> On Sat, Jun 6, 2015 at 10:11 AM, Joichi Ito wrote:

> Turns out membrane proteins are also amazing molecules for color =A6 colors of light change their geometry which our nerves can sense. =t's interesting how color goes from light -> molecular geometry =hange -> electrical energy in neuron -> shapes in visual cortex -> =hapes in our brain.

## >>

» Sorry, I'm still at the wrong scale, but...

>>

> > The math part is interesting. How do you think neurons and biology =ap onto ourbrain? Brains seem pretty messy compared to math.

>>

>> - Joi

>>

> > On Jun 6, 2015, at 9:49 AM, Jeffrey E. <jeevacation@gmail.com> =rote:

>>>

> » ive had a lot of back and forth with chomsky . the description =f some of these things that category theory helps frame is really =eautiful. . coherence, is a pretty and contiguous shape, =ymmetries. make it both simple and complex. . taking the donut and =wisting it into a know changes its topology and mathematics. Im =fraid I can begin to make the case for feng shui, . doesn't make me =appy but it can be organized into a symphony of light modulated inputs. =. ( I know its sounds a but woo woo. but it has serious math behind =t.

>>>

> > On Sat, Jun 6, 2015 at 9:39 AM, Joichi Ito wrote:

> > Maybe this is too microscopic, but Ed's work on =round-truthing science - the physics behind the biology and =huguang's work in understanding membrane proteins will probably =elp us understand cellular communication including the use of proteins =nd possibly other forces like magnetics and electrical and more crazy =hings.

>>>

> » I was remember the picture you had about the cells communicating =s an model of "pricing" of "value". The =hing is that the cells communicate and transact using proteins that =nteract with cells via membrane proteins. We have only discovered 500 =embrane proteins so far and the human genomes encodes for 8000 of which =e only have discovered 20. I'm not positive, but I think =nderstanding these membrane proteins will unlock a bunch of really =nteresting

## >> (cont.)

networks of communication both in the brain and between =uman beings that we don't understand yet. Shughuang has part of =he key, which is a way to identify these non-water soluble proteins =sing what is called a QTY conversion. Not sure if you're =nterested, but when we meet next, I should sit down and explain it to =ou if you don't already know. It's pretty fascinating. =n addition to figuring out how cells signal and how the networks of =roteins in our body work / environment work, this also unlocks many of =he secrets to smells.

>>>

> > I din't know this but it turns out that we have 5-10 =ifferent

> > membrane proteins per "odorant" that detects =ittle parts of the

> > bigger odorant molecule and they do this very fast. =ach membrane

> > protein senses part of the structure and they create an

> » =eurological signal based on this pattern and we figure out the

>> > smell =A6

## >>>

> » And the company we invested in, O2H is called O2H because the key =o understanding membrane proteins is to make the non-water-soluable =embrane proteins, water-soluable by converting the certain amino acids =hich retains the structure but changes the solubility so O2H is sort of =E2 water reversed". O2H has all of the commercialization =ights to this field of study.

>>>

> > But... more broadly...

>> >

> > there is one sort of random "sense"... it =urns out that we have a cluster of nerves in our optic nerve that only =ense blue light that sets our circadian. That's why they say =lue light affects mood and jet lag. These nerves have nothing to do =ith the nerves that we "see" with.

## >>>

> » We know for a fact that magnetics and electrical signals affect =he brain so I'm sure we can "sense" these.

## >>>

> » Have you heard of people who put super-magnets in their fingers to =ense metal?

>> >

>> =ttp://io9.com/what-you-need-to-know-about-getting-magnetic-finger

>>> -imp-813=37993

>>>

> > Tenzin would probably have some good thoughts on this.

>> >

> > > I also have a very smart guy who is trying to convince me that =his works:

>> >

>>>> http://tinyurl.com/qfoafft

## >>>

>>> http://tinyurl.com/nv8thk6

>>>

>> - Joi

>>>

> > > On Jun 6, 2015, at 8:49 AM, Jeffrey E. <jeevacation@gmail.com> =rote:

>>>

> > > my question , for today is how many senses to we really have.? = what are their ranges. do we sense infrared. without awareness. . =torm brewing etc.

## >>>

> > > On Sat, Jun 6, 2015 at 8:45 AM, Joi Ito rote:

> > » I remember Martin asking me some question a out w y sians =on't say answer things directly.

## >>>>>

> > » Here's sort of an answer to the opposite question. :-)

>>>>>

>>>>>> =ttp://www.quora.com/Why-are-Germans-so-nosey/answer/Yves-Gra

## >>>>> (cont.)

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## >>>>> (cont.)

>

> please note

> The information contained in this communication is confidential, may

> be attorney-client privileged, may constitute inside information, and

> is intended only for the use of the addressee. It is the property of

> JEE Unauthorized use, disclosure or copying of this communication or

> any part thereof is strictly prohibited and may be unlawful. If you

> have received this communication in error, please notify us

> immediately by return e-mail or by e-mail to jeevacation@gmail.com,

> and destroy this communication and all copies thereof, including all

> attachments. copyright -all rights reserved

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