<table><tr><th>From:</th><th>Ting, Jess</th></tr><tr><td>Sent:</td><td>Tuesday, February 19, 2013 10:30 PM</td></tr><tr><td>To:</td><td>Jeffrey Epstein</td></tr><tr><td>Subject:</td><td>Re: Research</td></tr></table>

Our research is based on the hypothesis that it is the micro-environment (e=g., the "normal" breast tissue surrounding a breast cancer in the case of =react cancer) that enables tumors to metastasize - rather than something i=trinsic to the tumors. There is much anecdotal evidence to support this an= it also explains several paradoxes about breast cancer - for example, why=extirpative surgery for breast cancer seems to cause a paradoxical rise ca=cer activity. This theory which is known as the "seed and soil" hypothesis=has been purely theoretical in the past because until now there was never =ay to study the microenvironment around these tumors without killing the h=st or killing the tissue itself.

We came up with the idea to use fluid that is routinely collected (but thro=n away) for 1-2 weeks after breast surgery as a proxy for the microenviron=ent around the tumor. Let me explain - after breast surgery to remove a c=ncerous breast, we routinely place a plastic drainage tube in the wound be= which exits the skin and drains excess blood and wound fluid into small p=astic reservoirs. This prevents buildup of unwanted blood and fluid after =urgery. This fluid is thrown away. The drains are kept in for a week or tw=. Our idea was that this fluid contains all the proteins, growth factors, =ytokines, DNA transcription factors etc that are secreted by the cells aro=nd a cancer and would make an ideal way of studying the microenvironment i= vivo.

For the last three years, we have been collecting wound fluid for the first=48 hours after breast cancer surgery. We compare fluid in the same patient=from the cancerous breast to the non-cancerous breast and from the cancero=s breast to the abdomen. In certain surgeries the opposite non-cancerous b=east is removed as a precaution or tissue from the abdomen is used to reco=struct the removed breast which is why we have access this fluid from then= sites as well. This "normal" fluid is used as a control for the fluid fro= the cancerous breast.

We have found differences in this fluid in both test tubes and in mice. Our=preliminary results are positive and show that this idea has validity. We =ant to continue to characterize this fluid from cancerous breasts and to c=llect more specimens. If we are successful, this will be a major advance i= understanding the mechanisms of cancer.

I supported this work with my own personal research fund.

I have spent $200,000 of my research fund (given to me patients) to pay for=a full time lab tech devoted to this project and for all of the supplies o=er the last three years. But my fund is down to $10,000. I have another do=ation of $100,000 coming into my fund that I will devote to this project b=t not until the end of the year. In the meantime, we would have to fire th= lab tech and stop collecting fluid specimens.

To bridge the period until my research fund will be replenished with the ex=ected $100,000 grant coming at the end of the year, we would need $50,000 =ideally more for a full-court press). It could even be in the form of a lo=n that is repaid with the future contribution.

Thanks for your consideration.

Jess Ting

On Feb 19, 2013, at 4:56 PM, "Jeffrey Epstein" <jeevacation@gmail.com<mailto:jeevacation@gmail.com>> wrote:

send more details

On Tue, Feb 19, 2013 at 4:51PM, Ting, Jess rote: Jeffrey, besides being a plastic surgeon, I also do basic science research =n breast cancer. My lab uses a novel approach that no one else in the worl= is doing. Our preliminary results are promising but we need funding to co=tinue to the next phase.

Would you consider financially supporting us?

I hope I haven't offended you by being too direct. If I have, I I apologize p=ofusely.

But if this is something that interests you, my lab partner and I would lov= to tell you more about it. I promise you would find it intellectually sti=ulating and interesting.

Warmest regards,

Jess Ting

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