From: ███ ███ <█████████████████████>
Sent: Monday, April 10, 2017 6:46 PM
To: Jeffrey Epstein
Subject: wow

This article has disappeared from the literature..having a real=y hard time locating

J Alzheimers Dis. <https://www.ncbi.nlm.nih.gov.offcampus.lib.washington.edu/pubmed/?term=Aluminum+and+Alzheimer%27s+disease%3A+after+a+ce=tury+of+controversy%2C+is+there+a+plausible+link%3F#> 2011;23(4):567-98. doi: 10.3233/JAD-2010-101494.

Al=minimum and Alzheimer's disease:=C2 after a century of controversy</=pan>, is there a plausible link?

Tomljenovic L <https://www.ncbi.nlm.nih.gov.off=ampus.lib.washington.edu/pubmed/?term=Tomljenovic%20L%5BAuthor%5D&ca=thor=true&cauthor_uid=21157018> 1.

<https://www-ncbi-nlm-nih-

gov.offcampus.lib.washington.edu/pubmed/?term=Aluminum+and+Alzheimer%27s+disease%3A+after+a+cent=ry+of+controversy%2C+is+there+a+plausible+link%3F#>

## 1

Neural Dynamics Research <u>Group, Department o= Ophthalmology and Visual Sciences,</u> University of British Columbia, Vancou=er, BC, Canada /a> <mailto

Abstract

The=brain is a highly compartmentalized organ exceptionally susceptible to acc=mulation of metabolic errors. Alzheimer's disease=/span> (AD) is the most prevalent neurodegenerative disease of the elderly and is characterized by regional specificity of ne=ral aberrations associated with higher cognitive functions. Aluminum=/span> (Al) is the most AD-susceptible abundant neurotoxic n=uronal foci. metal In on spite earth, of this, widely the bi=available role of Al in to AD humans has been and heavily repeatedly dispu=ed shown based to accumulate on the following in claims: 1) bioavailable Al cannot enter the brai= in sufficient amounts to cause damage, 2) excess Al is efficiently excret=d from the body, and 3) Al accumulation in neurons is a consequence rather=than a cause of neuronal loss. Research, however, reveals that: 1) very sm=ll amounts of Al are needed to produce neurotoxicity and this criterion is=satisfied through dietary Al intake, 2) Al sequesters different transport =echanisms to actively traverse brain barriers, 3) incremental acquisition =f small amounts of Al over a lifetime favors its selective accumulation in=brain tissues, and 4) since 1911, experimental evidence has repeatedly dem=nstrated that chronic Al intoxication reproduces neuropathological hallmar=s of AD. Misconceptions about Al bioavailability may have misled scientist= regarding the significance of Al in the pathogenesis of AD. The hypothesi= that Al significantly contributes to AD is built upon very solid experime=tal evidence and should not be dismissed. Immediate steps should be taken =o lessen human exposure to Al, which may be the single most aggravating an= avoidable factor related to AD.

P=ID:

## 1 (cont.)

DOI:

10.3233/JAD-2010-101494 <https://doi-or=.offcampus.lib.washington.edu/10.3233/JAD-2010-101494>