<table><tr><th>From:</th><th>Harvard PGP on behalf of
Harvard PGP</th></tr><tr><td>Sent:</td><td>Friday, March 10, 2017 11:48 PM</td></tr><tr><td>To:</td><td>Jeffrey</td></tr><tr><td>Subject:</td><td>Harvard PGP-Lumosity research study for memory and reaction speed</td></tr></table>

Dear Jeffrey,

The following is an invitation from a third party activity. While this act=vity is not conducted by Harvard PGP, we thought you might be intereste= in learning about it. You are receiving this because:

- You are enrolled in the Harvard Personal Gen=me Project

Note: This activity is reviewed by the Harvard Medical School Institutiona= Review Board but is separate from the Harvard PGP's study protoc=l. Third party activities have approval from their own IRB or equivalent=when applicable.

Thank you for your ongoing participation!
Harvard PGP

Dear=Harvard PGP participant,

We are initiating, in the form of a third party study, =a new genomics research project directed at the Harvard Personal Gen=me Project (PGP) community in partnership with an online gaming=platform Lumosity. We invite you to participate in our research study whi=h will measure your memory, attention and reaction speed by playing 6 d=fferent Lumosity games. The goal of the research is to identify genetic f=ctors that can help in developing treatments for neurodegenerative d=seases like Alzheimer's.

To participate in our study, please log into your PGP profile (https://my.pgp-hms.o=g) and click on the Third Party Activities link and click on the PGP-=umosity activity link. You will be directed to a consent page and given y=ur own personal login credentials to perform the games at Lumosity.

We hope that you will participate in our PGP-Lumosity study and have =reat fun with the set of 6 games that we have specially selected for=you!

For more information about the study, visit our webpage at https://wyss.harvard=2Eedu/PGP-lumosity Any questions? Please feel free to contact us at pgpresearch@wyss.harvard.edu <mailto:pg=research@wyss.harvard.edu> <=r> Thank you!

PGP-Lumosity research team

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Copyright © 2017 Harvard Personal Gen=me Project, All rights reserved. You are receiving this email because you are enrolled as a participant in=the Harvard Personal Genome Project.

Our mailing address is:

Harvard Personal Genome Projec=
Church Lab, NRB=238
77 Avenue Louis Pasteur
Boston, MA <=pan class="postal-code">02115

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