The study explores how a decline in NAD+ levels during aging induces a pseudohypoxic state that disrupts nuclear-mitochondrial communication, leading to mitochondrial dysfunction. It identifies a PGC-1α/β-independent pathway regulated by SIRT1 and HIF-1α that affects mitochondrial homeostasis. The research suggests that increasing NAD+ levels can restore mitochondrial function, offering potential therapeutic avenues for age-related diseases.
documents/EFTA00611136.pdf
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