The document presents a spatial model for tumor evolution, demonstrating how short-range dispersal and cell turnover can account for rapid cell mixing inside tumors. It shows that even a small selective advantage of a single cell within a large tumor allows its descendants to replace the precursor mass quickly. The model also explains the rapid onset of resistance to chemotherapy and suggests targeting short-range cellular migratory activity could affect tumor growth rates.
documents/EFTA00603737.pdf
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