The document is a scientific study on the evolutionary dynamics of RNA-guided gene drives, focusing on their potential applications and the theoretical understanding required before real-world application. It discusses the genetic manipulation of wild populations to address ecological and public health concerns, enabled by CRISPR/Cas9 technology. The study presents four distinct evolutionary trajectories for gene drives, including two counterintuitive ones, and explores the conditions for their spread and containment. It also highlights the importance of understanding gene drive resistance before application.
documents/EFTA01205594.pdf
{}