The document discusses the evolutionary dynamics of RNA-guided gene drives, focusing on their potential applications in ecological and public health issues. It explores the spread of gene drives through wild populations, the conditions for their success, and the potential for resistance. The study presents a model for understanding the long-term outcomes of gene drive release, identifying four distinct trajectories of drive spread. It also highlights the importance of understanding gene drive resistance before real-world application.
documents/EFTA00591446.pdf
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